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Combining Conventional Therapies with Intratumoral Injection of Autologous Dendritic Cells and Activated T Cells to Treat Patients with Advanced Cancers
Author(s) -
Mann Dean L.,
Celluzzi Christina M.,
Hankey Kim G.,
Harris Kristina M.,
Watanabe Ryuko,
Hasumi Kenichiro
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.04934.x
Subject(s) - medicine , immunotherapy , immune system , antigen , chemotherapy , dendritic cell , radiation therapy , adverse effect , antigen presenting cell , cancer , immunology , progressive disease , oncology , cancer research , t cell
Dendritic cells (DCs) are potent antigen‐presenting cells that have been used in cancer immunotherapy. To take advantage of the ability of DCs to acquire antigenic materials from their environment and generate primary as well as recall immune responses, 37 patients with advanced cancers were enrolled in a series of protocols based on direct intratumoral injection of immature DCs. To augment antigen uptake and antitumor immune response, DC injection was combined with radiotherapy or chemotherapy and/or injection of activated T cells. Treatments were well tolerated with no adverse reactions. Clinical responses were based on Response Evaluation Criteria in Solid Tumors, with the majority of patients showing stable disease. One of two patients who also received local radiation achieved a sustained complete response at injected and metastatic sites. The clinical responses observed in cancer patients with advanced disease suggest potential effectiveness of combination strategies and establish the basis for the current treatment protocol that is underway.