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Hematopoietic Stem and Progenitor Cells and the Inflammatory Response
Author(s) -
Jaiswal Siddhartha,
Weissman Irving L.
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.04930.x
Subject(s) - haematopoiesis , progenitor cell , stem cell , microbiology and biotechnology , biology , bone marrow , immune system , immunology , adult stem cell , endothelial stem cell , genetics , in vitro
Cells of the vertebrate immune system are continuously regenerated by division of hematopoietic stem cells (HSCs) into differentiated effector cells. Classically, HSCs were thought to reside primarily in the bone marrow niche where they produced mature progeny that migrated from the marrow to repopulate the peripheral immune system. However, emerging evidence has established that hematopoietic stem and progenitor cells (HSPCs) are themselves mobile and able to repopulate ectopic niches and contribute more directly to inflammatory responses in the periphery. How the HSPCs remain immune to destruction in a toxic inflammatory milieu is unknown.