Premium
Complement Cascade in Systemic Lupus Erythematosus
Author(s) -
Ceribelli Angela,
Andreoli Laura,
Cavazzana Ilaria,
Franceschini Franco,
Radice Antonella,
Rimoldi Laura,
Sinico Renato Alberto,
Carlsson Malin,
Wieslander Jorgen,
Tincani Angela
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.04921.x
Subject(s) - mannan binding lectin , complement system , pathogenesis , immunology , systemic lupus , complement (music) , systemic lupus erythematosus , lectin pathway , lupus erythematosus , antibody , alternative complement pathway , correlation , medicine , humoral immunity , disease , biology , lectin , genetics , gene , phenotype , geometry , mathematics , complementation
The complement (C') cascade is an important part of the innate immunity. It acts through three major pathways: classical (CP), alternative (AP) and mannose‐binding‐lectin (MP). C' reduction is a key feature in systemic lupus erythematosus (SLE), for its pathogenesis and for disease relapse. The aims of our study are to correlate C' variations with disease activity and verify the presence of C' deficiencies. We tested for three C' pathways 52 sera from 20 patients affected by SLE. A significant correlation between the ECLAM score and the degree of activation of the CP (Mann‐Whitney; P = 0.001) was recorded, while the correlation with anti‐dsDNA antibodies did not reach statistical significance (Mann‐Whitney; P > 0.05). In conclusion, the ELISA assay can be considered well suited for testing SLE samples. We detected a significant link between the phases of lupus activity and the reduction of the CP.