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Evaluation of Anti‐inflammatory and Analgesic Activity of a Novel Rigid 3, 4‐Dihydroxy Chalcone in Mice
Author(s) -
Heidari M. R.,
Foroumadi A.,
Amirabadi A.,
SamzadehKermani A.,
Azimzadeh B. S.,
Eskandarizadeh A.
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.04904.x
Subject(s) - analgesic , hot plate , nociception , hot plate test , chalcone , pharmacology , inflammation , anti inflammatory , medicine , drug , anesthesia , chemistry , materials science , receptor , stereochemistry , composite material
There have been many reports indicating the analgesic and anti‐inflammatory effects of 3,4‐dihydroxychalcones. We have designed and synthesized a rigid 3,4‐dihydroxychalcone (RDHC) as a possible drug effecting inflammation and nociception. The analgesic and anti‐inflammatory effects were evaluated by formalin and hot‐plate tests, respectively. The results showed that RDHC induced significant antinociceptive and anti‐inflammatory effects ( P < 0.01). Maximum analgesia (63.7%) was observed at 37.5 mg/kg in the first phase of the formalin test. The effect of RDHC was higher in the chronic phase (inflammation phase) of the formalin test (86.4%, P < 0.01). In addition, a significant analgesia (maximum possible effect; MPE = 30.1%) was observed in the hot plate test 45 min after injection of 37.5 mg/kg RDHC ( P < 0.01). As a result of our findings, this new RDHC could be suggested for further pharmacological studies.