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Multiple Mechanisms for Hydrogen Peroxide–Induced Apoptosis
Author(s) -
Cerella Claudia,
Coppola Simona,
Maresca Vittoria,
De Nicola Milena,
Radogna Flavia,
Ghibelli Lina
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.04901.x
Subject(s) - hydrogen peroxide , oxidative stress , apoptosis , chemistry , mitochondrion , oxidative phosphorylation , biophysics , microbiology and biotechnology , mitochondrial dna , reactive oxygen species , biochemistry , biology , gene
The mechanisms of cell killing by oxidative stress, in particular by hydrogen peroxide, are not yet well clarified. Here, we show that during recovery after H 2 O 2 treatment, apoptosis occurs in two different waves, peaking at 8 h (early) and 18 h (late) of recovery from oxidative stress. The two peaks are differentially modulated by a set of inhibitors of metabolic processes, which suggests that the first peak depends on DNA break formation, whereas the second may be correlated with H 2 O 2 ‐induced mitochondrial alterations.