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Expression of Vascular Endothelial Growth Factor and Hypoxia Inducible Factor‐1α in Cervical Neoplasia
Author(s) -
No Jae Hong,
Jo Hoenil,
Kim SuHyeong,
Park InAe,
Kang Daehee,
Han SeungSu,
Kim Jae Weon,
Park NohHyun,
Kang SoonBeom,
Song YongSang
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.04891.x
Subject(s) - immunohistochemistry , cervical cancer , vascular endothelial growth factor , angiogenesis , cervical intraepithelial neoplasia , carcinogenesis , medicine , cervix , pathology , hypoxia (environmental) , cancer research , cancer , oncology , vegf receptors , chemistry , organic chemistry , oxygen
Altered angiogenesis is an important phenotype of high‐grade cervical lesions and invasive cervical carcinomas. Many researchers, including us, have shown that oncoproteins of human papillomavirus could enhance the vascular endothelial growth factor (VEGF) expression. We investigated the change in VEGF and hypoxia‐inducible factor‐1α (HIF‐1α) expression patterns that occur during the carcinogenesis and progression of cervical cancer. Expressions of HIF‐1α and VEGF were evaluated by immunohistochemistry using paraffin‐embedded specimens obtained from 41 patients with a normal cervix, 39 patients with cervical intraepithelial neoplasia (CIN 1, 10; CIN 2/3, 29), and 36 patients with cervical cancer. The VEGF and HIF‐1α expressions were higher in CIN and invasive cancer than in normal cervix ( P = 0.021, P < 0.001, respectively). It is interesting to note that there was no significant difference in VEGF and HIF‐1α overexpressions between CIN 2/3 and cervical cancer and between nonmetastatic and metastatic cancers. In addition, there was a significant correlation between the immunohistochemical score of HIF‐1α and that of VEGF expression (Spearman's correlation coefficient 0.275, P = 0.003, n = 116). Taken together, the results of our study suggest that expressions of VEGF and HIF‐1α could be involved in cervical carcinogenesis. In addition, the weak correlation between VEGF and HIF‐1α expressions suggests that regulatory mechanisms other than HIF‐1α may be involved in the expression of VEGF during cervical carcinogenesis.