Premium
Hyperactivity Induced by Antiphospholipid Syndrome Serum
Author(s) -
Menachem Assaf,
Chapman Joab,
Katzav Aviva
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.04876.x
Subject(s) - antiphospholipid syndrome , medicine , thrombosis , pregnancy , saline , anxiety , endocrinology , immunology , psychiatry , biology , genetics
Antiphospholipid syndrome (APS) is a multisystem disorder characterized by arterial and venous thrombosis, pregnancy morbidity, and neuropsychiatric manifestations. Antiphospholipid IgG injected intracerebro‐ventricularly (ICV) cause behavioral hyperactivity in mice. In the present study we investigated the effects of APS whole‐serum ICV administration in female Balb/C mice. Control mice were injected with serum derived from healthy subjects or saline solution. Behavior was assessed by the staircase apparatus which combines locomotor (stair‐climbing) exploratory activities and rearing as a measure of anxiety. Mice injected with serum from APS patients or serum from normal subjects showed a trend to an increase in the number of stairs climbed in the APS group. The results suggest a differential effect of specific IgG and other serum components in the CNS manifestations of APS.