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Sex Differences in a Murine Model of Sjögren's Syndrome
Author(s) -
Čiháková Daniela,
Talor Monica V.,
Barin Jobert G.,
Baldeviano G. Christian,
Fairweather DeLisa,
Rose Noel R.,
Burek C. Lynne
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.04760.x
Subject(s) - sjögren syndrome , medicine , chemistry , autoimmune disease , disease
Sex differences in a NOD.H2 h4 murine model of Sjögren's syndrome were analyzed. Compared to males, female NOD.H2 h4 mice have increased severity of sialoadenitis and have a significantly increased percentage of CD4 + T cells in salivary gland infiltrates. CD4 + T cells in female infiltrates produce more Th2 and Th17 cytokines than in males, while males have greater Th1 responses. Females also have enhanced B cell responses, with higher levels of SSA and SSB serum antibodies, and B cell activation factor F (BAFF). Thus, sex has a strong impact on the severity of murine Sjögren's syndrome by affecting the immune mechanisms driving the autoimmune inflammation.