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HLA‐B27 Transgenic Rat
Author(s) -
Milia Anna Franca,
IbbaManneschi Lidia,
Manetti Mirko,
Benelli Gemma,
Messerini Luca,
MatucciCerinic Marco
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.04757.x
Subject(s) - hla b27 , genetically modified mouse , transgene , human leukocyte antigen , inflammatory bowel disease , immunology , gene , biology , disease , medicine , genetics , pathology , antigen
The HLA‐B27 gene is strongly associated with the spondyloarthropathies (SpA), a group of chronic inflammatory diseases affecting the bowel, the joints, and the axial skeleton. Yet the basis for this association remains unknown, despite extensive study in the past years. The HLA‐B27 transgenic rat spontaneously develops a disease that strikingly resembles human SpA. The purpose of this article is to review the contribution of studies on the HLA‐B27 transgenic rat model aimed to elucidate the intimate relationship between gut and joint involvement in SpA.