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Cyclooxygenase‐2 Expression in Cervical Intraepithelial Neoplasia
Author(s) -
Kim Kidong,
Jeon YongTark,
Park InAe,
Kim Jae Weon,
Park NohHyun,
Kang SoonBeom,
Lee HyoPyo,
Song YongSang
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.04724.x
Subject(s) - stromal cell , immunohistochemistry , epithelium , cervical intraepithelial neoplasia , pathology , carcinogenesis , medicine , intraepithelial neoplasia , cyclooxygenase , stroma , biology , cervical cancer , cancer , enzyme , prostate , biochemistry
To evaluate the role of cyclooxygenase (COX)‐2 during cervical carcinogenesis, we investigated COX‐2 expression in the dysplastic epithelium and stromal cells of cervical intraepithelial neoplasia (CIN). Immunohistochemical analysis with COX‐2 antibody was performed on 148 paraffin‐embedded tissue specimens of patients who were diagnosed as CIN in our institute. COX‐2 expression was evaluated separately in the dysplastic epithelium and stromal cells of CIN. The relationships between COX‐2 expression and clinicopathologic variables were examined. For the dysplastic epithelium, COX‐2 expression was negative in 137 (92.6%) and positive in 11 (7.4%) specimens. For the stromal cells, COX‐2 expression was negative in all specimens. The COX‐2 expression in dysplastic epithelium was higher in older ( P = 0.038) or postmenopausal ( P = 0.025) women. In conclusion, COX‐2 expression was observed only in the dysplastic epithelium but not in the stromal cells of CIN. The COX‐2 expression in dysplastic epithelium was associated with age and menopausal status.