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Preventing Viral‐induced Type 1 Diabetes
Author(s) -
Richer Martin Joseph,
Horwitz Marc Steven
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.04662.x
Subject(s) - type 2 diabetes , immunity , type 1 diabetes , immunology , peripheral tolerance , function (biology) , diabetes mellitus , medicine , biology , autoimmunity , virology , immune system , microbiology and biotechnology , endocrinology
The development of type 1 diabetes is, in part, dictated by the failure of regulatory T cells to maintain peripheral tolerance. As such, therapies aimed at correcting the declining function of regulatory T cells have been the subject of intense investigation. In this review, we discuss the potential of regulatory T cells to suppress autoreactive responses and prevent type 1 diabetes induced by viral infection while maintaining protective antiviral immunity.