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Cytokines and Anxiety in Systemic Lupus Erythematosus (SLE) Patients Not Receiving Antidepressant Medication
Author(s) -
FigueiredoBraga Margarida,
MotaGarcia Fernando,
O’Connor JoséEnrique,
Garcia Juan Rafael,
MotaCardoso Rui,
Cardoso Carla Sofia,
De Sousa Maria
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.04647.x
Subject(s) - immunology , anxiety , autoimmunity , medicine , acquired immune system , systemic lupus erythematosus , antidepressant , disease , immune system , psychiatry
Autoimmunity travelled from the theoretical roots planted by Burnet with the clonal selection theory and the early finding of a mouse providing a test for the role of the thymus as a source of forbidden clones. This chapter briefly reviews early work with the NZB mouse and presents results of an analysis of associations between cytokines and physical and psychometric parameters in systemic lupus erythematosus (SLE) patients not medicated with antidepressants. Some cytokines, particularly IFN‐γ, relate significantly to physical symptoms and anxiety. We conclude with the speculation that anxiety is linked to innate immunity and more severe neuropsychiatric disease in SLE to adaptive immunity.