Premium
Association of Polymorphisms in Interleukin‐10 Gene Promoter with Autoantibody Production in Patients with Rheumatoid Arthritis
Author(s) -
Nemec Petr,
Goldbergova Monika Pavkova,
Gatterova Jindra,
Vasku Anna,
Soucek Miroslav
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.04625.x
Subject(s) - autoantibody , rheumatoid arthritis , haplotype , immunology , single nucleotide polymorphism , allele , genotype , medicine , rheumatoid factor , arthritis , gene , biology , genetics , antibody
Interleukin‐10 (IL‐10) is a major anti‐inflammatory cytokine that plays a crucial role in the regulation of the immune system. Allelic polymorphisms in the IL‐10 gene promoter may contribute to the regulation of autoantibody production. To examine the association between both individuals IL‐10 single nucleotide polymorphisms and the production of autoantibodies and the radiographic progression of rheumatoid arthritis (RA), a total of 144 RA patients were recruited into the study. We found significant differences in genotype distribution of the ‐1082G/A polymorphism between IgG, IgA, and IgM rheumatoid factor(RF)‐positive/negative RA patients. We also found significant differences in allelic frequencies of the ‐3575T/A, ‐819C/T, and ‐592A/C polymorphisms between anticyclic citrullinated peptide (anti‐CCP)‐positive/negative RA patients. The haplotype TGAATA was found to be less frequent within anti‐CCP‐positive RA patients. Results obtained in this study provide evidence of an association between polymorphisms in IL‐10 gene promoter and the production of autoantibodies in RA patients.