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Lymphoid Lineage Fate Decision of Hematopoietic Stem Cells
Author(s) -
Akashi Koichi
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.04570.x
Subject(s) - haematopoiesis , stem cell , lineage (genetic) , hematopoietic stem cell , biology , microbiology and biotechnology , genetics , gene
To understand the mechanism in lymphoid development, it is critical to identify developmental intermediates downstream of hematopoietic stem cells, including cells responsible for seeding the thymus. Although early studies showed that hematopoietic stem cells choose either the myeloid‐erythroid or the lymphoid pathway, recent data suggest that myelo‐lymphoid precursors lacking erythroid potential exist in early hematopoiesis before cells are fully committed to the lymphoid lineage. We here summarize the phenotype and functional properties of such progenitors and the current developmental map for the lymphoid lineage.