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Intracellular Life of Coxiella burnetii in Macrophages
Author(s) -
Ghigo Eric,
Pretat Lionel,
Desnues Benoît,
Capo Christian,
Raoult Didier,
Mege JeanLouis
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.04515.x
Subject(s) - coxiella burnetii , q fever , intracellular , phagosome , intracellular parasite , obligate , phagocytosis , myeloid , biology , macrophage , microbiology and biotechnology , immunology , biochemistry , ecology , in vitro
Coxiella burnetii , the agent of Q fever, is an obligate intracellular bacterium that is considered a potential biological weapon of category B. C. burnetii survives within myeloid cells by subverting receptor‐mediated phagocytosis and preventing phagosome maturation. The intracellular fate of C. burnetii also depends on the functional state of myeloid cells. This review describes the mechanisms used by C. burnetii to circumvent uptake and trafficking events, and the role of cytokines on C. burnetii survival in myeloid cells.