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Cadherin‐Mediated Regulation of Tight Junctions in Stratifying Epithelia
Author(s) -
Michels Christian,
Aghdam Saeed Yadranji,
Niessen Carien M.
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.04443.x
Subject(s) - tight junction , cadherin , barrier function , microbiology and biotechnology , polarity (international relations) , function (biology) , epidermis (zoology) , cell junction , septate junctions , biology , chemistry , gap junction , anatomy , genetics , intracellular , cell
In recent years several seminal breakthroughs have revealed that tight junctions not only regulate barrier properties of simple epithelial cells but also play crucial functions in the regulation of the largest barrier of the organism, the stratifying epidermis of the skin. Here we will address the importance of tight junctions for the skin barrier function and discuss data from our studies and from others that indicate how cadherins, polarity, and other pathways may regulate these junctions in stratifying epithelia.