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The Role of Claudin‐Based Tight Junctions in Morphogenesis
Author(s) -
Furuse Mikio,
Moriwaki Kazumasa
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.04441.x
Subject(s) - claudin , tight junction , morphogenesis , hydrostatic pressure , microbiology and biotechnology , septate junctions , chemistry , biology , gap junction , physics , mechanics , genetics , intracellular , gene
In morphogenetic events during developmental processes, the hydrostatic pressure caused by fluid accumulation is thought to be an important factor determining the shape of epithelial structures. Recent studies using loss of function of claudins have demonstrated that tight junctions, by their control of fluid accumulation, have crucial roles in morphogenesis. Interestingly, both the barrier and the channel functions of tight junctions appear to contribute to morphogenesis.