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Adrenocorticotropic Hormone, Melanocyte‐stimulating Hormone, and the Melanocortin Receptors: Revisiting the Work of Robert Schwyzer
Author(s) -
Dores Robert M.
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.04434.x
Subject(s) - melanocortin , adrenocorticotropic hormone , receptor , melanocyte stimulating hormone , melanocortin 3 receptor , hormone , endocrinology , medicine , melanocortin receptor , hormone receptor , biology , cancer , breast cancer
In 1977 Dr. Robert Schwyzer wrote the review ACTH: A Short Introductory Review , which provided a reference point for current structure/function studies on the interactions between adrenocorticotropic hormone and α‐melanocyte‐stimulating hormone and the melanocortin receptors. This mini review will evaluate how the predictions made in the 1977 review have held up and also propose a mechanism to explain the ligand selectivity properties of the melanocortin receptors.