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Author(s) -
Graham W. Vallen,
Marchiando Amanda M.,
Shen Le,
Turner Jerrold R.
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.04050.x
Subject(s) - myosin light chain kinase , tight junction , microbiology and biotechnology , intracellular , myosin , chemistry , immunoglobulin light chain , biophysics , biology , immunology , antibody
Permeability of the intestinal epithelial barrier is regulated in response to physiological and pathophysiological stimuli. Recent work has characterized a critical role of acute tight junction regulation in diarrhea secondary to T cell activation and cytokine release. The intracellular mediators of the ensuing barrier dysfunction include myosin light chain kinase, which phosphorylates myosin II regulatory light chain and triggers structural tight junction reorganization. While the molecular intermediates in this reorganization are not defined, the new discovery that individual tight junction–associated proteins are highly dynamic at steady state may provide insight into the mechanisms of regulation.