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Evaluation of Relaxin's Antifibrotic Action by SELDI‐TOF Mass Spectrometry‐Based Profiling of Relaxin Knockout Mice, a Model of Progressive Fibrosis
Author(s) -
Giannakis Eleni,
Macris Mary,
Chan Linda,
Tregear Geoffrey W.,
Samuel Chrishan S.,
Wade John D.
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.03957.x
Subject(s) - relaxin , knockout mouse , chemistry , fibrosis , mass spectrometry , endocrinology , medicine , pharmacology , receptor , chromatography , biochemistry
Surface‐enhanced laser desorption ionization–time‐of‐flight mass spectrometry was employed to identify potential biomarkers for early‐onset fibrosis. These biomarkers were then used to evaluate the efficacy of relaxin to reverse or ameliorate the development of the condition.