Premium
Metabotropic Glutamate Receptors and Dendrodendritic Synapses in the Main Olfactory Bulb
Author(s) -
Dong HongWei,
Heinbockel Thomas,
Hamilton Kathryn A.,
Hayar Abdallah,
Ennis Matthew
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.03891.x
Subject(s) - olfactory bulb , neuroscience , metabotropic glutamate receptor , neurotransmission , olfactory system , olfaction , glutamate receptor , ionotropic effect , olfactory receptor , biology , metabotropic receptor , metabotropic glutamate receptor 5 , central nervous system , receptor , biochemistry
The main olfactory bulb (MOB) is the first site of synaptic processing in the central nervous system for odor information that is relayed from olfactory receptor neurons in the nasal cavity via the olfactory nerve (ON). Glutamate and ionotropic glutamate receptors (iGluRs) play a dominant role at ON synapses. Similarly, glutamate and iGluRs mediate dendrodendritic transmission between several populations of neurons within the MOB network. Neuroanatomical studies demonstrate that metabotropic glutamate receptors (mGluRs) are densely expressed through the MOB network, and they are particularly abundant at dendrodendritic synapses. Until recently, the physiological roles of mGluRs in the MOB were poorly understood. Over the past several years, mGluRs have been shown to play surprisingly powerful neuromodulatory roles at ON synapses and in dendrodendritic neurotransmission in the MOB. This chapter focuses on recent advances in our understanding of mGluR‐mediated signaling components at dendrodendritic synapses.