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Organization, Integration, and Assembly of Genetic and Epigenetic Regulatory Machinery in Nuclear Microenvironments
Author(s) -
Stein Gary S.,
Zaidi Sayyed K.,
Stein Janet L.,
Lian Jane B.,
Van Wijnen Andre J.,
Montecino Martin,
Young Daniel W.,
Javed Amjad,
Pratap Jitesh,
Choi JeYong,
Ali Syed A.,
Pande Sandhya,
Hassan Mohammad Q.
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.03697.x
Subject(s) - epigenetics , biology , transcription factor , computational biology , regulation of gene expression , carcinogenesis , chromatin , context (archaeology) , gene , gene expression , genetics , microbiology and biotechnology , paleontology
There is growing awareness that the fidelity of gene expression necessitates coordination of transcription factor metabolism and organization of genes and regulatory proteins within the three‐dimensional context of nuclear architecture. The regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised with the onset and progression of tumorigenesis. High throughput imaging of cells, tissues, and tumors, including live cell analysis, is expanding research's capabilities toward translating components of nuclear organization into novel strategies for cancer diagnosis and therapy.