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Relaxin in Endometriosis
Author(s) -
Morelli Sara S.,
Petraglia Felice,
Weiss Gerson,
Luisi Stefano,
Florio Pasquale,
Goldsmith Laura T.
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2008.03792.x
Subject(s) - relaxin , endometriosis , matrix metalloproteinase , endometrium , vascular endothelial growth factor , infertility , vegf receptors , medicine , pelvic pain , growth factor , endocrinology , receptor , cancer research , andrology , biology , pregnancy , surgery , genetics
Endometriosis is an important contributing factor to chronic pelvic pain and infertility. Matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) have each been implicated in the establishment of endometriotic lesions. Since relaxin regulates the expression of MMPs and VEGF in the endometrium, we tested the hypothesis that relaxin plays a role in endometriosis by comparing the expression of relaxin mRNA and its LGR7 (RXFP1) receptor mRNA in normal human endometrium to those in samples from patients with endometriosis.