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INSL3 Plays a Role in the Balance between Bone Formation and Resorption
Author(s) -
Pepe Anastasia,
Ferlin Alberto,
Gianesello Lisa,
Facciolli Arianna,
Agoulnik Alexander I.,
Foresta Carlo
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2008.03785.x
Subject(s) - osteoblast , bone resorption , osteoclast , chemistry , stimulation , resorption , in vitro , microbiology and biotechnology , bone formation , endocrinology , medicine , hormone , biology , biochemistry
We have recently demonstrated that the disruption of the INSL3 hormonal system, as observed in humans with mutations in the RXFP2 gene and in Rxfp2 ‐deficient mice, might affect the equilibrium of the osteoblast–osteoclast system, resulting in an imbalance between bone formation and bone resorption that may result in reduced bone mass. In the present study we have better characterized the in vitro effects of INSL3 on human osteoblasts. Stimulation of human primary osteoblasts with INSL3 at serial concentrations (1 pM, 1 nM, and 1 μM) induced a dose‐dependent increase in osteoblast proliferation and expression of specific osteoblast genes.