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APRP, the Second Peptide Encoded by the Adipokinetic Hormone Gene(s), Is Highly Conserved in Evolution
Author(s) -
De Loof Arnold,
Vandersmissen Tim,
Huybrechts Jurgen,
Landuyt Bart,
Baggerman Geert,
Clynen Elke,
Lindemans Marleen,
Husson Steven J.,
Schoofs Liliane
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2008.03638.x
Subject(s) - adipokinetic hormone , peptide , gene , biology , growth hormone , cloning (programming) , hormone , genetics , biochemistry , fat body , computer science , programming language
Since the early days of cloning the first adipokinetic hormone ( AKH ) gene, researchers recognized that this gene also codes for a joining region and for a second peptide called adipokinetic hormone precursor related peptide (APRP). In species with more than one AKH gene, such as locusts, APRPs can form both homodimers and heterodimers. Database analysis showed that APRPs might belong to the ancient family of growth hormone releasing factor but they still are functionally orphan. We investigated whether some of the APRP forms play a role in control of reproduction or/and growth via stimulation of ecdysteroidogenesis.