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Further Insights into the Insulin‐like Growth Factor‐I System of Bony Fish Pituitary with Special Emphasis on Reproductive Phases and Social Status
Author(s) -
Shved Natallia,
Baroiller JeanFrançois,
Eppler Elisabeth
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2008.03632.x
Subject(s) - medicine , endocrinology , paracrine signalling , biology , growth factor , insulin like growth factor , hormone , somatotropic cell , luteinizing hormone , gonadotropic cell , pituitary gland , melanocyte stimulating hormone , receptor
Insulin‐like growth factor (IGF)‐I, which is crucially involved in fish growth, differentiation, and reproduction, occurs in tilapia pituitary. IGF‐I peptide, which is probably produced in hypothalamic perikarya, is present in axons of the neurohypophysis, and IGF‐I mRNA and peptide are present in the adenohypophysis in adrenocorticotrophic hormone cells, melanocyte‐stimulating hormone cells, with interindividual differences in growth hormone cells, and, starting with puberty, in gonadotrophic hormone (GTH) cells. Subordinate males showed a high IGF‐I but a lower β‐luteinizing hormone expression, while in dominant males the opposite was found. IGF‐I from the GTH cells may act as auto/paracrine regulators of GTH cell proliferation and enhance GTH synthesis and release during puberty and reproduction, depending on the social status.