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Novel Neuroprotective Tripeptides and Dipeptides
Author(s) -
FADEN ALAN I.,
KNOBLACH SUSAN M.,
MOVSESYAN VILEN A.,
LEA PAUL M.,
CERNAK IBOLJA
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2005.tb00057.x
Subject(s) - neuroprotection , nootropic , tripeptide , dipeptide , chemistry , neuroscience , in vivo , pharmacology , medicine , peptide , biology , biochemistry , microbiology and biotechnology
A bstract : It has long been recognized that thyrotropin‐releasing hormone (TRH) and certain TRH analogues are neuroprotective in a variety of animal models of CNS trauma. In addition to these neuroprotective actions, TRH and most TRH analogues have other physiological actions that may not be desirable for treatment of acute injury, such as analeptic, autonomic, and endocrine effects. We have developed a series of dual‐substituted TRH analogues that have strong neuroprotective actions, but are largely devoid of these other physiological actions. In addition, we have developed a family of cyclized dipeptides (diketopiperazines), structurally somewhat related to a metabolic product of TRH, that appear even more effective as neuroprotective agents in vitro and in vivo , and may have nootropic properties. Here, we review these novel tripeptide and dipeptide compounds.