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N ‐Acetyldopamine Inhibits Rat Brain Lipid Peroxidation Induced by Lipopolysaccharide
Author(s) -
OXENKRUG GREGORY F.,
REQUINTINA PURA J.
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2005.tb00047.x
Subject(s) - lipopolysaccharide , lipid peroxidation , lipid a , chemistry , pharmacology , biochemistry , medicine , oxidative stress
A bstract : The effects of N ‐acetyldopamine, a sepiapterin reductase inhibitor, on lipopolysaccharide‐induced lipid peroxidation were examined in rat brain homogenates in vitro . Lipid peroxidation in the form of malondialdehyde (MDA) was evaluated by the measurement of thiobarbituric acid (TBA) reactive substances. N ‐Acetyldopamine inhibited the formation of MDA in a concentration‐dependent manner. The effect was similar to that of N ‐acetylserotonin, but stronger than that of the endogenous antioxidant agent, melatonin. Possible clinical applications of N ‐acetyldopamine and its derivatives are discussed.