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Convergent Pathobiologic Model of Parkinson's Disease
Author(s) -
MAGUIREZEISS KATHLEEN A.,
FEDEROFF HOWARD J.
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2003.tb07473.x
Subject(s) - disease , parkinson's disease , neuroscience , transgene , animal model , medicine , etiology , neurodegeneration , bioinformatics , biology , genetics , psychiatry , pathology , gene
A bstract : The etiology of Parkinson's disease (PD) has yet to be delineated. Human genetic studies as well as neurotoxicant and transgenic animal models of PD suggest that multiple events trigger the initiation of this progressive age‐related neurodegenerative disorder. In addition, we propose that despite disparate disease triggers a convergent pathobiologic pathway exists leading to cell death. The common pathway model posits that both familial and sporadic forms of Parkinson's disease obligately share a common pathophysiological substrate. Herein we discuss the evidence for a common pathway model of Parkinson's disease through a review of synuclein transgenic models and outline an approach for the idenfication of shared therapeutic targets. We end with a discussion of a potential alternative therapy for Parkinson's disease.