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Parkinson's Disease and Related α‐Synucleinopathies Are Brain Amyloidoses
Author(s) -
TROJANOWSKI JOHN Q.,
LEE VIRGINIA MY.
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2003.tb07468.x
Subject(s) - synucleinopathies , neurodegeneration , neuroscience , parkinson's disease , disease , amyloid (mycology) , alpha synuclein , biology , medicine , pathology
A bstract : A paradigm shift in understanding Parkinson's disease (PD) and related disorders is emerging from studies showing that alpha‐synuclein (AS) gene mutations cause familial PD; AS is abnormally nitrated, phosphorylated, and ubiquitinated; AS forms neuronal and glial inclusions; AS fibrillizes in vitro ; and AS transgenic animals develop neurodegeneration with AS amyloid inclusions. Thus, PD and related synucleinopathies are brain amyloidoses that may share similar mechanisms and targets for drug discovery.