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Cat Scratch Disease with Lymphadenitis, Vertebral Osteomyelitis, and Spleen Abscesses
Author(s) -
ROLAIN J. M.,
CHANET V.,
LAURICHESSE H.,
LEPIDI H.,
BEYTOUT J.,
RAOULT D.
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2003.tb07399.x
Subject(s) - bartonella henselae , cat scratch disease , vertebral osteomyelitis , osteomyelitis , pathology , medicine , serology , lymph node , lymph node biopsy , spleen , disease , antibody , immunology
A bstract : In this report we describe a 30‐year old male patient with vertebral osteomyelitis and spleen abscesses with cat scratch disease. The diagnosis was made on the basis of molecular detection of Bartonella henselae either on lymph node biopsies or on bone biopsy, histology of the lymph node, serology using either our in‐house microimmunofluorescence assay or a commercial kit (Focus Technologies). Immunofluorescent detection was also performed directly on slide appositions using a monoclonal antibody. Treatment consisted of administration of antibiotics with rapid clinical improvement and a stabilization of skeletal lesions on the magnetic resonance imaging performed three months later. Twenty two other cases of this unusual manifestation associated with cat scratch disease have been reported in the literature and are reviewed here. Our case represents the second case of osteomyelitis associated with cat scratch disease in which B. henselae has been specifically identified as the etiological agent using several direct and indirect methods.