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Ouabain as a Mammalian Hormone
Author(s) -
SCHONER WILHELM,
BAUER NATALI,
MÜLLEREHMSEN JOCHEN,
KRÄMER ULRIKE,
HAMBARCHIAN NJDE,
SCHWINGER ROBERT,
MOELLER HANS,
KOST HOLGER,
WEITKAMP CHRISTINE,
SCHWEITZER THOMAS,
KIRCH ULRIKE,
NEU HORST,
GRÜNBAUM ERNSTGÜNTHER
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2003.tb07282.x
Subject(s) - ouabain , digoxin , chemistry , endocrinology , medicine , hormone , steroid , cardiac glycoside , epinephrine , endogeny , pharmacology , biochemistry , biology , sodium , heart failure , organic chemistry
A bstract : Endogenous ouabain changes rapidly in humans and dogs upon physical exercise and is under the control of epinephrine and angiotensin II. Hence, the steroid acts as a rapidly acting hormone. A search for a specific binding globulin for cardiac glycosides in bovine plasma resulted in the identification of the d allotype of the μ chain of IgM whose hydrophobic surfaces interact with cardiotonic steroids and cholesterol. Such IgM complexes might be involved in the hepatic elimination of cardiotonic steroids. Thus, differences in the signaling cascade starting at Na + ,K + ‐ATPase must explain any differences in the action of ouabain and digoxin in the genesis of arterial hypertension.