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Dendritic Cells
Author(s) -
BANCHEREAU JACQUES,
PACZESNY SOPHIE,
BLANCO PATRICK,
BENNETT LYNDA,
PASCUAL VIRGINIA,
FAY JOSEPH,
PALUCKA A. KAROLINA
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2003.tb06047.x
Subject(s) - microbiology and biotechnology , dendritic cell , immune system , secretion , immunology , function (biology) , follicular dendritic cells , biology , myeloid , immunity , chemistry , antigen presenting cell , t cell , biochemistry
A bstract : The immune system is controlled by dendritic cells (DCs). Just as lymphocytes comprise different subsets, DCs comprise several subsets that differentially control lymphocyte function. In humans, the myeloid pathway includes Langerhans cells (LCs) and interstitial DCs (intDCs). While both subsets produce IL‐12, only intDCs make IL‐10 and induce B cell differentiation. Another pathway includes plasmacytoid DCs, which promptly secrete large amounts of IFN‐α/β viral encounter. Thus, insights into in vivo DC functions are important to understand the launching and modulation of immunity.