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Mechanisms Inducing or Controlling CD8 + T Cell Responses against Self‐ or Non‐Self‐Antigens
Author(s) -
ACCAPEZZATO DANIELE,
FRANCAVILLA VITTORIO,
PROPATO ANTONELLA,
PAROLI MARINO,
BARNABA VINCENZO
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2003.tb06037.x
Subject(s) - cytotoxic t cell , major histocompatibility complex , antigen , antigen processing , antigen presentation , cd8 , microbiology and biotechnology , immunology , mhc class i , cross presentation , t cell , self tolerance , autoimmunity , biology , antigen presenting cell , immune system , chemistry , genetics , in vitro
A bstract : Cytotoxic T lymphocytes (CTLs) generally recognize antigens en‐dogenously synthesized within the cells and presented in the form of peptides on class I molecules. However, a large body of evidence suggests that dendritic cells (DCs) have the capacity to capture and deliver exogenous antigens into the major histocompatibility complex (MHC) class I processing pathway. In this paper, we discuss this function, defined as cross‐presentation, and how it is directed, particularly in inducing T cell tolerance, and how it requires special activating signals (such as CD40 ligand) to transform into a mechanism that provides either protective immunity or autoimmunity.