Premium
Activation‐Induced Cytidine Deaminase Links Class Switch Recombination and Somatic Hypermutation
Author(s) -
OKAZAKI ILMI,
YOSHIKAWA KIYOTSUGU,
KINOSHITA KAZUO,
MURAMATSU MASAMICHI,
NAGAOKA HITOSHI,
HONJO TASUKU
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2003.tb06027.x
Subject(s) - somatic hypermutation , cytidine deaminase , activation induced (cytidine) deaminase , immunoglobulin class switching , cytidine , biology , genetics , gene conversion , gene , dna , somatic cell , recombination , mutation , rna , microbiology and biotechnology , enzyme , biochemistry , antibody , b cell
A bstract : Activation‐induced cytidine deaminase (AID), a putative RNA‐editing cytidine deaiminase that is expressed strictly in activated B cells, is indispensable in three apparently distinct genetic alterations of immunoglobulin genes—namely, class switch recombination, somatic hypermutation, and gene conversion. Recent findings led us to propose a common DNA cleaving mechanism, in which the transient secondary structure of the S and V region DNA is recognized by a nicking enzyme regulated by the putative RNA‐editing activity of AID.