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Genetic and Epigenetic Mosaicism in Cancer Precursor Tissues
Author(s) -
TYCKO BENJAMIN
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2003.tb05961.x
Subject(s) - epigenetics , loss of heterozygosity , biology , dna methylation , genetics , cancer , methylation , genomic imprinting , epigenesis , dna , gene , allele , gene expression
A bstract : The concept of field effects in cancer is old, but recent molecular data have substantiated it. Clones of cells that carry well‐defined genetic or epigenetic aberrations, but which have not yet acquired the morphological hallmarks of neoplasia, have been documented in the precursor tissues of some of the most common pediatric and adult malignancies. Here I review this evidence, focusing on loss of heterozygosity (LOH) and gain of DNA methylation.