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Nonpeptide Mediators in the Hematopoietic Microenvironment
Author(s) -
MÖHLE ROBERT,
BOEHMLER ANDREAS M.,
DENZLINGER CLAUDIO,
KANZ LOTHAR
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2003.tb03233.x
Subject(s) - homing (biology) , chemokine receptor , microbiology and biotechnology , chemokine , cxcr4 , progenitor cell , haematopoiesis , chemotaxis , chemistry , receptor , cd34 , cell adhesion , plerixafor , stem cell , biology , cell , biochemistry , ecology
A bstract : Migration of hematopoietic stem and progenitor cells (HPCs) is controlled by chemotactic factors released in the hematopoietic microenvironment. In particular, the chemokine SDF‐1, which activates the G protein‐coupled receptor (GPR) CXCR4, plays an important role in progenitor cell mobilization and homing. However, we provide evidence that ligands of other GPRs similarly act on CD34 + hematopoietic progenitors. These ligands comprise non‐peptide mediators, including the cysteinyl‐leukotriene receptor CysLT1, and stimulate migration and integrin‐dependent adhesion of HPCs. Moreover, continuous activation of a GPR by a specific ligand upregulates the responsiveness of other GPRs to their corresponding ligands. These findings suggest that HPC migration may not depend on a single chemokine receptor (e.g., CXCR4). Rather, mobilization and homing of HPCs involve several GPRs, which interact with each other as well as with adhesion molecules. Pharmacological activation and inhibition of the GPR may allow HPC mobilization and homing to be modulated.