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The Role of Neural Inflammation in Asthma and Chronic Obstructive Pulmonary Disease
Author(s) -
JOOS GUY F.,
SWERT KATELIJNE O.,
SCHELFHOUT VANESSA,
PAUWELS ROMAIN A.
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2003.tb03152.x
Subject(s) - neurokinin a , bronchoconstriction , substance p , tachykinin receptor , medicine , asthma , immunology , tachykinin receptor 1 , neurogenic inflammation , chronic bronchitis , proinflammatory cytokine , inflammation , receptor , neuropeptide
A bstract : The tachykinins substance P and neurokinin A are found within airway nerves and immune cells. They have various effects on the airways that can contribute to the changes observed in asthma and chronic obstructive pulmonary disease. Both tachykinin NK 1 and NK 2 receptors have been involved in the bronchoconstriction and the proinflammatory changes induced by substance P and neurokinin A. Tachykinin NK 1 and NK 2 receptor antagonists have activity in various animal models of allergic asthma and chronic bronchitis. It is suggested that dual NK 1 /NK 2 and triple NK 1 /NK 2 /NK 3 tachykinin receptor antagonists have potential in the treatment of obstructive airway diseases.