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Results of Long‐Term Experimental Studies on the Carcinogenicity of Formaldehyde and Acetaldehyde in Rats
Author(s) -
SOFFRITTI MORANDO,
BELPOGGI FIORELLA,
LAMBERTIN LUCA,
LAURIOLA MICHELINA,
PADOVANI MICHELA,
MALTONI CESARE
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04926.x
Subject(s) - acetaldehyde , carcinogen , formaldehyde , physiology , toxicity , toxicology , chemistry , medicine , endocrinology , biology , biochemistry , ethanol
A bstract : Formaldehyde was administered for 104 weeks in drinking water supplied ad libitum at concentrations of 1500, 1000, 500, 100, 50, 10, or 0 mg/L to groups of 50 male and 50 female Sprague‐Dawley rats beginning at seven weeks of age. Control animals (100 males and 100 females) received tap water only. Acetaldehyde was administered to 50 male and 50 female Sprague‐Dawley rats beginning at six weeks of age at concentrations of 2,500, 1,500, 500, 250, 50, or 0 mg/L. Animals were kept under observation until spontaneous death. Formaldehyde and acetaldehyde were found to produce an increase in total malignant tumors in the treated groups and showed specific carcinogenic effects on various organs and tissues.