Premium
Results of Long‐Term Carcinogenicity Bioassays on Tert ‐Amyl‐Methyl‐Ether (TAME) and Di‐Isopropyl‐Ether (DIPE) in Rats
Author(s) -
BELPOGGI FIORELLA,
SOFFRITTI MORANDO,
MINARDI FRANCO,
BUA LUCIANO,
CATTIN ELISA,
MALTONI CESARE
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04925.x
Subject(s) - ether , bioassay , isopropyl , carcinogen , chemistry , olive oil , isopropyl alcohol , body weight , toxicology , medicine , medicinal chemistry , organic chemistry , biology , food science , genetics
A bstract :Tert ‐amyl‐methyl ether (TAME) was administered by gavage in extra virgin olive oil solution at concentrations of 750, 250, or 0 mg/kg bw to groups of 100 male and 100 female Sprague‐Dawley rats 8 weeks old at the start of the experiment. Di‐isopropyl ether (DIPE) was administered in the same manner at the doses of 1000, 250, or 0 mg/kg body weight to groups of 100 male and 100 female Sprague‐Dawley rats. TAME and DIPE were each delivered in 1‐mL solution 4 days a week for 78 weeks. Control animals received 1 mL of extra virgin olive oil without TAME or DIPE. At the end of the treatment period, all animals were kept under observation until spontaneous death. Under these test conditions, TAME and DIPE were found to be potential carcinogenic agents for various organs and tissues.