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β‐Amyloid Fragment 25–35 Selectively Damages Platelets from Patients with Alzheimer's Disease
Author(s) -
CASOLI TIZIANA,
DI STEFANO GIUSEPPINA,
DELFINO ALESSIA,
SOLAZZI MORENO,
FATTORETTI PATRIZIA,
BERTONIFREDDARI CARLO,
GUIDI MARCO,
SCARPINO OSVALDO,
GIUNTA SERGIO,
GALEAZZI LUCIANO
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04829.x
Subject(s) - platelet , amyloid (mycology) , chemistry , calcium in biology , intracellular , calcium , β amyloid , disease , alzheimer's disease , pathology , biochemistry , medicine , immunology , organic chemistry
A bstract : In order to analyze the metabolic response of AD patient platelets to β‐amyloid, we have carried out fluorimetric measurements of intracellular calcium and an ultrastructural survey of platelets exposed to the β‐amyloid active fragment 25–35 (βA 25‐35 ). Since it is not possible to analyze directly the damaged neurons in AD, the study of peripheral blood cells, especially platelets, may be of great value for the investigation of the toxic effects of β‐amyloid on AD neuronal cells.