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Enhanced Aβ 40 Deposition Was Associated with Increased Aβ 42/43 in Cerebral Vasculature with Dutch‐Type Hereditary Cerebral Hemorrhage with Amyloidosis (HCHWA‐D)
Author(s) -
OZAWA K.,
TOMIYAMA T.,
MAATSCHIEMAN M. L.,
ROOS R. A.,
MORI H.
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04810.x
Subject(s) - cerebral amyloid angiopathy , amyloidosis , pathology , senile plaques , angiopathy , amyloid (mycology) , medicine , alzheimer's disease , intracerebral hemorrhage , pathological , stroke (engine) , disease , endocrinology , dementia , mechanical engineering , subarachnoid hemorrhage , engineering , diabetes mellitus
A bstract : Cerebrovascular deposition of the amyloid beta‐protein (Aβ) is a common pathologic event in patients with Alzheimer's disease (AD) and certain related disorders. Such an Aβ vascular deposition occurs primarily in the medial layer of the cerebral vessel wall in an assembled fibrillar state. These deposits are associated with several pathological responses, including degeneration of the smooth muscle cells in the cerebral vessel wall. Severe cases of cerebrovascular Aβ deposition are also accompanied by loss of vessel wall integrity and hemorrhagic stroke. Although the reasons for this pathological consequence are unclear, altered proteolytic mechanisms within the cerebral vessel wall may be involved. We analyzed cerebral Aβ deposition in brains with AD and Dutch‐type hereditary cerebral hemorrhage with amyloidosis (HCHWA‐D) on the basis of two amyloid species of Aβ 40 and Aβ 42/43 using specific monoclonal antibodies. Compared to Aβ deposition in senile plaques, the molecular composition of Aβ was distinguishable, indicating that the Aβ 40 species is the main component for vascular amyloid. Furthermore, we found Aβ 42/43 immunoreactivity was also much increased in amyloid angiopathy of all cases with HCHWA‐D. Taken together, amyloid angiopathy in HCHWA‐D may share an Aβ 42 ‐driven deposition mechanism with plaque amyloid, resulting in enhanced Aβ 40 deposition.