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Binding of the Retinal Rod Na + /Ca 2+ ‐K + Exchanger to the cGMP‐Gated Channel Indicates Local Ca 2+ ‐Signaling in Vertebrate Photoreceptors
Author(s) -
BAUER PAUL J.
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04755.x
Subject(s) - chemistry , physics , biophysics , biology
A bstract : Ca 2+ ions enter the outer segment of rod or cone photoreceptors exclusively through the cGMP‐gated channel and are extruded by the Na + /Ca 2+ ‐K + exchanger. Recent evidence indicates that in the plasma membrane, the Na + /Ca 2+ ‐K + exchanger is associated with the cGMP‐gated channel. In this contribution, the possible physiologic significance of this protein complex is considered. Based on recent experimental evidence, the possibility of a direct functional interaction between the cGMP‐gated channel and the Na + /Ca 2+ ‐K + exchanger is discussed. Furthermore, a quantitative estimation of the cytoplasmic Ca 2+ diffusion at the cGMP‐gated channel indicates that Ca 2+ diffusion is largely confined to the complex of the cGMP‐gated channel and the associated Na + /Ca 2+ ‐K + exchanger molecules.