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Type I Insulin‐like Growth Factor Receptor Expression on Colorectal Adenocarcinoma Cell Lines Is Decreased in Response to the Chemopreventive Agent N ‐Acetyl‐l‐Cysteine
Author(s) -
KELLY RAYMOND G.,
NALLY KENNETH,
SHANAHAN FERGUS,
O'CONNELL JOE
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04700.x
Subject(s) - cancer research , colorectal cancer , growth factor , cell culture , insulin like growth factor , cell growth , chemistry , receptor , adenocarcinoma , insulin like growth factor receptor , medicine , endocrinology , biology , cancer , biochemistry , genetics
A bstract : Increased expression of the type I insulin‐like growth factor receptor (IGF‐1R) is associated with colon cancer, while the antioxidant N ‐acetyl‐l‐cysteine (NAC) is known to suppress colonic proliferation. We demonstrate that NAC down‐regulates the expression of IGF‐1R on three colorectal adenocarcinoma cell lines (HT29, SW480, and LoVo). NAC also abrogates the proliferative effect of IGF‐I on HT29 cells. This indicates a novel mechanism for the therapeutic effects of NAC.