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Curcumin Induces Caspase‐3‐Independent Apoptosis in Human Multidrug‐Resistant Cells
Author(s) -
PIWOCKA KATARZYNA,
BIELAKMIJEWSKA ANNA,
SIKORA EWA
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04643.x
Subject(s) - curcumin , apoptosis , tunel assay , chemistry , programmed cell death , caspase , caspase 3 , multiple drug resistance , caspase 9 , microbiology and biotechnology , cancer research , biology , biochemistry , antibiotics
A bstract : Curcumin, the major component of the spice turmeric, used in 50‐μM concentration, induced cell death in multidrug‐resistant CEM P‐gp4 and LoVo P‐gp4 cells as well as in their sensitive counterparts as assessed by TUNEL method and morphological observation. In all cells induced to undergo cell death with curcumin, there was no caspase‐3 activation because only the unprocessed form of caspase‐3 was observed using immunoblotting.