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The Role of Mitogen‐Activated Protein Kinases and Their Relationship with NF‐κB and PPARγ in Indomethacin‐Induced Apoptosis of Colon Cancer Cells
Author(s) -
KIM TAE IL,
JIN SOO HYUN,
KANG EUN HYE,
SHIN SUNG KWAN,
CHOI KANG YELL,
KIM WON HO
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04641.x
Subject(s) - p38 mitogen activated protein kinases , apoptosis , kinase , mitogen activated protein kinase , mapk/erk pathway , cancer research , peroxisome proliferator activated receptor , receptor , chemistry , protein kinase a , nf κb , colorectal cancer , signal transduction , medicine , microbiology and biotechnology , cancer , biology , biochemistry
A bstract : We have evaluated the role of mitogen‐activated protein kinases (MAPKs) and their relationship with nuclear factor κB (NF‐κB) and peroxisome proliferator‐activated receptor γ (PPARγ) in indomethacin‐induced apoptosis of colon cancer cells. We demonstrated that indomethacin can induce the prolonged activation of MAPKs in colon cancer cells; and that of these MAPKs, p38 MAPK may play a partial but significant role in indomethacin‐induced apoptosis. Furthermore, indomethacin‐induced p38 MAPK‐mediated apoptosis of colon cancer cell lines is independent of caspase activation and not associated with indomethacin‐induced NF‐κB suppression and PPARγ activation.