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Further Immunohistochemical Evidence for Impaired NO Signaling in the Hypothalamus of Depressed Patients
Author(s) -
BERNSTEIN H.G.,
HEINEMANN A.,
KRELL D.,
MAWRIN C.,
BIELAU H.,
DANOS P.,
DIEKMANN S.,
KEILHOFF G.,
BOGERTS B.,
BAUMANN B.
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04613.x
Subject(s) - nitric oxide synthase , hypothalamus , immunohistochemistry , neuronal nitric oxide synthase , endocrinology , medicine , depression (economics) , nitric oxide , signal transduction , chemistry , biology , microbiology and biotechnology , economics , macroeconomics
A bstract : The cellular expression of nitric oxide synthase (NOS) was studied in neurons of the Nuc. suprachiasmaticus (SCN) of depressed patients and matched controls. The number of NOS‐immunoreactive SCN neurons was significantly reduced in depression. We conclude that affective disorders are accompanied by impaired hypothalamic NO signaling.