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Hepatic Insulin‐like Growth Factor‐I Binding Protein 3 Gene Expression in Rats with Endotoxic Shock: The Role of Glucocorticoids
Author(s) -
PRIEGO T.,
CÁCERES I. IBAÑEZ,
MARTÍN A. I.,
VILLANÚA M. A.,
LÓPEZCALDERÓN A.
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04612.x
Subject(s) - endocrinology , medicine , lipopolysaccharide , endotoxic shock , insulin like growth factor binding protein , gene expression , growth factor , insulin , glucocorticoid , insulin like growth factor , biology , gene , chemistry , receptor , biochemistry
A bstract : The aim of this work was to study the role of glucocorticoids in the insulin‐like growth factor binding protein (IGFBP)‐3 response to endotoxin. Lipopolysaccharide (LPS) administration decreased IGFBP‐3 serum levels as well as hepatic IGFBP‐3 gene expression in both adrenalectomized and sham‐operated rats. These data suggest that the decrease in hepatic IGFBP‐3 gene expression induced by LPS is not mediated by glucocorticoids.