Premium
The Role of PPAR‐γ/RXR‐α Heterodimers in the Regulation of Human Trophoblast Invasion
Author(s) -
FOURNIER THIERRY,
PAVAN LAETITIA,
TARRADE ANNE,
SCHOONJANS KRISTINA,
AUWERX JOHAN,
ROCHETTEEGLY CECILE,
EVAINBRION DANIELE
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04601.x
Subject(s) - peroxisome proliferator activated receptor , trophoblast , retinoid x receptor , microbiology and biotechnology , ppar agonist , agonist , placenta , endocrinology , chemistry , medicine , biology , receptor , transcription factor , nuclear receptor , fetus , biochemistry , pregnancy , gene , genetics
A bstract : PPAR‐γ/RXR heterodimers play a key regulatory role in murine placental development. We report here that PPAR‐γ and RXR‐α are highly expressed in cultured primary extravillous cytotrophoblasts (EVCT) isolated from human first‐trimester placenta. Using this cell culture model, we showed that PPAR‐γ agonists inhibit EVCT invasion, whereas PPAR‐γ or pan‐RXR antagonists promoted EVCT invasion by themselves and abolished PPAR‐γ agonist‐mediated effect. Together these data underscore an important function of PPAR/RXR heterodimers in the modulation of trophoblast invasion.