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Modeling the Spreading Cortical Depression Wavefront
Author(s) -
BAYSAL UGUR,
HAUEISEN JENS
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04562.x
Subject(s) - cortical spreading depression , migraine , cortex (anatomy) , depolarization , depression (economics) , wavefront , neuroscience , magnetic resonance imaging , electroencephalography , medicine , optics , psychology , physics , radiology , economics , macroeconomics
A bstract : Spreading cortical depression (SCD) is a wave of depolarization that spreads across the cortex at 2–5 mm/min and is followed by a 5–10 minute reduction in EEG activity. It is assumed that SCD is involved in the pathophysiology of migraine. We present a new model and a visualization technique for the spread of excitation on realistic brain surfaces. The usefulness of the technique is demonstrated on a rat brain that had been segmented from a three‐dimensional magnetic resonance image data set. With the help of this methodology it is possible to create specific patient models to better understand the mechanisms of SCD.